Actual football question, offensive line rotation.

Definitely there is less energy involved as linemen aren't chasing linebackers and defensive backs to block them 50 yards away from the snap (30-40 yards downfield) unless it is a screen.

Often times, you will see d-linemen fake a rush, and drop back in pass coverage. That combined with constant lateral pursuit means much more running for d-linemen than o-linemen.

Yea, the rotation has more to do with package or scheme rather than rest. For instance, a jumbo in obvious short yardage or max protect in obvious passing downs.

Good answers so far. Just want to chime in and say that I played running back, defensive end, linebacker, and right guard on the o line between 7th and 12th grade. I never had more fun than when I got to be the fat kid on the offensive line.

Some good answers but I'd add that reaction takes more energy than action. Offensive players rarely get gassed unless they'running routes or long TD's.

I think its all been about covered. Two thoughts I agree with most:
-cohesion on the OL needs continuity and trust that comes from reps playing together. OL is a unit that must play in unison to be effective. Plug and play would be disruptive.
-offense always have the advantage as they know where the play is going, using less energy than the Ds who are in reaction/disruption mode.

Like somebody said, on a pass play a defensive lineman is basically in a sprint against 300+ lbs of resistance. Offensive lineman can't go downfield on passes, but defensive linemen are trying to get up the field then will chase after the pass, particularly against these dink and dunk pass attacks.

On run plays, they are often getting double teamed or if not for the full play for the initial part of the play (or trying to tie up more than one blocker) so trying to fight through 600+ lbs at that point.