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Pathways that extend lifespan by 500 percent identified

Posted on 1/12/20 at 7:19 pm
Posted by Trumansfangs
Town & Country
Member since Sep 2018
6899 posts
Posted on 1/12/20 at 7:19 pm
ScienceDaily


Scientists have identified synergistic cellular pathways for longevity that amplify lifespan fivefold in C. elegans, a nematode worm used as a model in aging research. The increase in lifespan would be the equivalent of a human living for 400 or 500 years, according to one of the scientists.



( Much more in the SD link )
Posted by kywildcatfanone
Wildcat Country!
Member since Oct 2012
119195 posts
Posted on 1/12/20 at 7:22 pm to
So, 425 years in a nursing home? No thanks.
Posted by Arksulli
Fayetteville
Member since Aug 2014
25198 posts
Posted on 1/12/20 at 8:23 pm to
This presents a dilemma if it is even half way effective in human beings. The current system of retirement, across the developed world, is under siege in that it wasn't built into the system that people would live beyond 65, other than the occasional outlier.

Now people, especially women, routinely live into the mid 80s.

What happens when we have a society where people live into their 200s? There is an uproar, and I won't get into that or we will Poliboard Tards invading, that Baby Boomers have held onto power a bit too long and choked out opportunities for the following generations.

Imagine that but the Baby Boomers live to be 250 and are fully capable of working for, say, 200 of those years. Think of the stagnation that would cause across the board. Are you a brilliant executive? Well you just have to wait a 125 years to move up the ranks.

I want to live to be 500. I might see Arkansas win another national title in football if I pull that off. But if I do live to be 500 I'm going to be taking up a shite load of space and resources. Mostly, I grant you, in booze.
Posted by Trumansfangs
Town & Country
Member since Sep 2018
6899 posts
Posted on 1/12/20 at 8:28 pm to
No no, we just wouldnt age as quickly.

" The paper focuses on how longevity is regulated in the mitochondria, which are the organelles in the cell responsible for energy homeostasis. Over the last decade, accumulating evidence has suggested a causative link between mitochondrial dysregulation and aging. Rollins' future research will focus on the further elucidation of the role of mitochondria in aging, he said."


Waiting until we're 75 to get a drivers license might be tough though.
Posted by tigerfoot
Alexandria
Member since Sep 2006
56329 posts
Posted on 1/12/20 at 10:26 pm to
I am 50 now, if we going to stop this train, lets do it in a hurry. I don't want 400 years of arthritis
Posted by madmaxvol
Infinity + 1 Posts
Member since Oct 2011
19160 posts
Posted on 1/13/20 at 7:47 am to
So, the question is...how would even doubling our lifespan impact the population growth curve. Those people who otherwise would be dying off will still be consuming food and producing waste. How long until the majority of humans are starving from a lack of food or suffering from contamination because we don't have anyplace for our waste?
Posted by Kentucker
Cincinnati, KY
Member since Apr 2013
19351 posts
Posted on 1/13/20 at 9:30 am to
A lengthening of lifespan would mandate control of birthrate. Natural resources are already spread super thin with the nearly 8 billion people on the planet. A sea change in ideas about the number of humans earth can support would be necessary. Forced sterilizations, forced abortions, amniocentesis selection and childless marriages would have to become routine.
Posted by AllbyMyRelf
Virginia
Member since Nov 2014
3327 posts
Posted on 1/13/20 at 9:58 am to
TR Malthus has already been proven wrong.
Posted by waiting4saturday
Covington, LA
Member since Sep 2005
9721 posts
Posted on 1/13/20 at 12:06 pm to
why would you want to live 500 years? frick that.
Posted by Trumansfangs
Town & Country
Member since Sep 2018
6899 posts
Posted on 1/13/20 at 2:32 pm to
quote:

why would you want to live 500 years? frick that.


You'd only be middle aged at 250.


Can't you imagine going to the fair or carnival and the midway age guesser pegs you to be 45 ? Haha wrong ! Im 256 !
You'd rack up on free ride tickets alone !

Ditch that whole cryogenics for extended space travel bs too !

Its a win/win ! :)
Posted by thatguy45
Your alter's mom's basement
Member since Sep 2017
18890 posts
Posted on 1/13/20 at 3:37 pm to
quote:

lengthening of lifespan would mandate control of birthrate. Natural resources are already spread super thin with the nearly 8 billion people on the planet.

If we could develop space travel as well as capabilities to effectively colonize planets mineral resources, living space, and ground for agriculture would be less of an issue.

Would have to figure out an energy solution as oil is not exactly prevalent elsewhere. The smaller nuclear reactor patented by the navy might (eventually) lead to a fix. But then all that would take a long time to do, don't know how far off lengthening life with a similar method in humans is
Posted by Miznoz
St. Louis
Member since Dec 2018
2147 posts
Posted on 1/13/20 at 9:58 pm to
I love this thread. Lots of science fiction has been written on this problem. If people could suddenly live that long in a few years it'd be such a cluster frick.
Posted by 14caratgoldjones
Uniontown, Al
Member since Aug 2009
1318 posts
Posted on 1/14/20 at 12:05 am to
Sweet. I can work another 320 years before I retire. Just the news I wanted to hear.
Posted by awestruck
Member since Jan 2015
10944 posts
Posted on 1/14/20 at 5:53 am to
... and your kids get to freeload until they're 73.

eta:

... unfortunately musician's sill die at 29.
... and Gus's buyout will go to 149million next time around.
This post was edited on 1/14/20 at 6:30 am
Posted by Kcprogguitar
Kansas City
Member since Oct 2014
889 posts
Posted on 1/14/20 at 10:02 am to
What makes you think the common man will have access?

This, even more than the wealth itself, would be the differentiator between the mega rich and everyone else.
Posted by Pavoloco83
Acworth Ga. too many damn dawgs
Member since Nov 2013
15347 posts
Posted on 1/14/20 at 8:45 pm to
Im interested if:

1. I can stay this good looking forever.
2. I can get a hard on on demand forever.
3. I can divorce and remarry every 40 years.
4. I dont have to pay taxes after the first 80 years
5. I get the right to murder one person ever 100 years penalty free.
Posted by Presidio
Member since Nov 2017
3060 posts
Posted on 1/14/20 at 8:55 pm to
Quality of life, not quantity
Posted by Buddy2012
Georgia
Member since Sep 2012
2861 posts
Posted on 1/15/20 at 5:26 am to
Would only be available to the extreme wealthy.
Posted by BearNickandLadies
Marion County, Alabama
Member since Dec 2019
259 posts
Posted on 1/15/20 at 11:48 am to
quote:

This presents a dilemma if it is even half way effective in human beings. The current system of retirement, across the developed world, is under siege in that it wasn't built into the system that people would live beyond 65, other than the occasional outlier.

Now people, especially women, routinely live into the mid 80s.

What happens when we have a society where people live into their 200s? There is an uproar, and I won't get into that or we will Poliboard Tards invading, that Baby Boomers have held onto power a bit too long and choked out opportunities for the following generations.

Imagine that but the Baby Boomers live to be 250 and are fully capable of working for, say, 200 of those years. Think of the stagnation that would cause across the board. Are you a brilliant executive? Well you just have to wait a 125 years to move up the ranks.

I want to live to be 500. I might see Arkansas win another national title in football if I pull that off. But if I do live to be 500 I'm going to be taking up a shite load of space and resources. Mostly, I grant you, in booze


good synopsis.

Perhaps non sequitur, but the Booomers need to go on... they have held on to everything for too damn long. Now the X'ers like myself as well as the Mills & Z'ers are going to have to try to hold their own while simultaneously supporting the Booms.

Booms are an incredibly selfish generation... I witnessed it growing up in the 70s how entitled they thought they were... You think college kids now are spoiled? Maybe they are, but those 1960s and 70s Boomer college students were god awful... hardly had to fork over a dime for tuition compared to what kids are paying today.


The rich Boomer Banker Elites have made it near impossible for today's youth to pay for education without taking out loans... only way out is to 1) have wealthy parents who can pay or 2) be super smart and get enough scholarships to pay it off in-state. Still doesn't account for the high cost of living on or near most campuses either.

Two of mine attend BAMA, one attends UAH. Very proud of them. My oldest, he earned HOPE and nearly a full ride to BAMA for his ACT score... he got a 32 I believe. My two girls, the twins, just started last year- one at BAMA and the other at UAH. Unfortunately they will have to take out loans because they have no choice. I can pay off a part, they can pay off a part, but there is still a lot left over and that's even being in-state.

Have any of you other parents seen how damn expensive those books are??? That's just dirty what these publishers do because the students have no choice but to buy them. When I was in comm. College back in 1985, books for the whole semester cost me $25. Now kids have to spend HUNDREDS on JUST BOOKS. yes, BOOKS. Outrageous! My oldest, he is about to graduate w/ a Mech. Eng. degree in May and his book cost has been north of $300 every semester at BAMA.


Anyway, rant over, just letting you know young people, I'm 53, and while I may be old I got your backs. It sure was easier to move up back then... I hurt for the kids today. No wonder they aren't expected to earn as much as us and especially the Booms. Unfair and Un-American!
Posted by Randman
Mississippi
Member since Feb 2018
313 posts
Posted on 1/15/20 at 12:21 pm to
Extra long human lifespans has been tried before with disastrous results:

“Then the Lord said, “My Spirit will not put up with humans for such a long time, for they are only mortal flesh. In the future, their normal lifespan will be no more than 120 years.”....
The Lord observed the extent of human wickedness on the earth, and he saw that everything they thought or imagined was consistently and totally evil. So the Lord was sorry he had ever made them and put them on the earth. It broke his heart. And the Lord said, “I will wipe this human race I have created from the face of the earth. Yes, and I will destroy every living thing—all the people, the large animals, the small animals that scurry along the ground, and even the birds of the sky. I am sorry I ever made them.””
Genesis 6:3-7
This post was edited on 1/15/20 at 12:23 pm
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