re: Has anybody ever taken Lexapro and had a personality change?

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Many moons ago I had this realization that at some time in the future there would be a humongous computer program that would simulate the entire human body on the molecular level.

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That would be a wonderful approach for testing drugs, but the reality is much more "hands on." No such program has been developed, to my knowledge.

The particular DNA study in which I participated deals primarily with the body's ability to metabolize medications. If the liver and its processes make all of a dose available to the brain, for example, then that drug is likely to be far more effective than would be one which is mostly ignored by the liver and is excreted by the body. It would also, of course, be made available to the brain much more quickly.

This study doesn't just apply to psychoactive drugs, but any that might be ingested by the body. People respond individually to the effects of drugs and this analysis points up those drugs that are likely to be most effective for the person being tested.