
bayoubengals88
| Favorite team: | |
| Location: | LA |
| Biography: | Formerly a fan of this website |
| Interests: | Conifers |
| Occupation: | |
| Number of Posts: | 26255 |
| Registered on: | 9/10/2007 |
| Online Status: | Not Online |
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re: Are there not levels of punishment in hell >>??
Posted by bayoubengals88 on 9/27/26 at 8:19 pm to Summer of Jimbo
I’ve been a Christian all my life. Still am.
I find the notion of physical hell to be nearly absurd.
I’m mostly fine with saying “I don’t know. Love others the best you can.”
I find the notion of physical hell to be nearly absurd.
I’m mostly fine with saying “I don’t know. Love others the best you can.”
re: Biotech Long Play: ABVX
Posted by bayoubengals88 on 9/27/26 at 6:14 pm to TheOcean
I’ve never seen an R/R from Claude above 78…
Clean slate — pure common equity, no options structure, no assumed position. Risk/reward purely on business quality and valuation at Friday's close.
## FULL RANKING — Common Shares Only, Current Price
| Rank | Ticker | Price | R/R Score | Why |
|---|---|---|---|---|
| 1 | **ABVX** | $91.06 | **84** | Phase 3 succeeded twice, NDA filing imminent, cash >$500M, no debt. Clinical risk is gone — the remaining risk is purely whether and when a pharma acquirer pays up. As equity, this is closest to a "the hard part is done" story on the list. |
| 2 | **VST** | $138.46 | **80** | Nuclear/gas power generator, near 52-week low, CEO bought at $135 in the open market, reasonable 21-23x P/E, pays a dividend. Real earnings, real cash flow, a business that improves in a high-rate/high-oil environment. |
| 3 | **OMDA** | $19.72 | **75** | Digital health, GAAP profitable, cash-rich, no debt, beat-and-raise every quarter since IPO. Cleanest growth-plus-profitability combination on the list. |
| 4 | **ZETA** | $29.45 | **73** | Marketing SaaS, positive free cash flow, 20 consecutive beat-and-raise quarters. Near its 52-week high now, so less margin of safety than a month ago — that's the only knock. |
| 5 | **OUST** | $43.72 | **69** | Real revenue growing 56%, 49% gross margin, $263M cash, zero debt, genuine smart-infrastructure moat. Up 15% recently, so you're paying more for the same quality. |
| 6 | **GRAB** | $3.13 | **67** | Southeast Asian super-app, buying back its own stock at the lows, insiders reportedly buying the dip today. Cheap on every metric relative to growth. BofA just cut its target, which tags real near-term uncertainty. |
| 7 | **NBIS** | $237.33 | **66** | Best AI-infrastructure business on the list, but P/S near 48x is genuinely rich, and today's tape shows a live AI-safety-driven selloff hitting the whole sector. As pure equity with no defined-risk structure, this is the most valuation-sensitive name here. |
| 8 | **IDN** | $2.39 | **64** | Pristine balance sheet — 91% gross margin, zero debt, cash-generative — held back entirely by one customer's unresolved vendor review. As a share, you're buying the balance sheet cheap and betting on a binary resolving well in November. |
| 9 | **ADTN** | $7.13 | **60** | Fiber-buildout turnaround, 0.93x EV/Sales genuinely cheap, but debt/equity of 1.87 in a 4.9% rate world is a real risk you fully absorb as a shareholder with no options cushion. |
| 10 | **BROS** | $37.89 | **58** | RSI at 20.85 — extremely oversold, near 52-week low. Real business, real growth, but 90x price-to-free-cash-flow and decelerating same-store sales make this a mean-reversion bet more than a quality-compounder bet at these levels. |
| 11 | **KRMN** | $34.92 | **54** | 56% revenue growth and a $1.3B backlog are real. Negative free cash flow and the JCap short-thesis are unresolved. November 5 earnings decides which story wins. |
| 12 | **ABSI** | $9.74 | **53** | Eli Lilly's $40M strategic investment is real validation. As straight equity you carry full exposure to a binary clinical readout due before year-end with no downside cushion. |
| 13 | **QXO** | $12.43 | **51** | Brad Jacobs is 5-for-5 across prior roll-ups. 6-7x leveraged against a housing-sensitive business is a real risk you own outright as a shareholder — no defined-loss structure. |
| 14 | **IVVD** | $0.93 | **48** | Approved commercial drug, cash roughly equal to market cap, Phase 3 data due any day. As common stock, full binary exposure both ways — genuinely could be a 5x or a total loss depending on data landing this week. |
| 15 | **YSS** | $9.57 | **46** | Up ~20% off the lows, which is a real recovery signal. But the 96%-customer-concentration allegation and the securities class action are both still unresolved. |
| 16 | **BKSY** | $23.25 | **40** | EBITDA-positive inflection was real, but the re-rating from $15 to $23 has already happened. Buying here means paying up for a story the market has mostly caught onto. |
| 17 | **VELO** | $11.29 | **32** | Down 29% with no confirmed catalyst in what I've verified. Structural ATM dilution was always the risk; something clearly hit the stock hard. Needs investigation before any conclusion — flagging honestly rather than guessing. |
| 18 | **SWMR** | $20.73 | **28** | $310K of revenue against a market cap in the hundreds of millions. Fell 5.64% same-day specifically on dilution and execution concerns tied to the Ratel deal — the exact risk materializing in real time. |
| 19 | **ARBE** | ~$0.60 | **20** | Just priced a dilutive offering with warrants for 24.17 million additional shares — roughly 19% of the share count — at a discount to market. Pre-revenue, cash-burning, and the dilution risk is no longer theoretical. As common stock with no leverage or defined-loss protection, this is the weakest risk/reward on the list right now. |
Clean slate — pure common equity, no options structure, no assumed position. Risk/reward purely on business quality and valuation at Friday's close.
## FULL RANKING — Common Shares Only, Current Price
| Rank | Ticker | Price | R/R Score | Why |
|---|---|---|---|---|
| 1 | **ABVX** | $91.06 | **84** | Phase 3 succeeded twice, NDA filing imminent, cash >$500M, no debt. Clinical risk is gone — the remaining risk is purely whether and when a pharma acquirer pays up. As equity, this is closest to a "the hard part is done" story on the list. |
| 2 | **VST** | $138.46 | **80** | Nuclear/gas power generator, near 52-week low, CEO bought at $135 in the open market, reasonable 21-23x P/E, pays a dividend. Real earnings, real cash flow, a business that improves in a high-rate/high-oil environment. |
| 3 | **OMDA** | $19.72 | **75** | Digital health, GAAP profitable, cash-rich, no debt, beat-and-raise every quarter since IPO. Cleanest growth-plus-profitability combination on the list. |
| 4 | **ZETA** | $29.45 | **73** | Marketing SaaS, positive free cash flow, 20 consecutive beat-and-raise quarters. Near its 52-week high now, so less margin of safety than a month ago — that's the only knock. |
| 5 | **OUST** | $43.72 | **69** | Real revenue growing 56%, 49% gross margin, $263M cash, zero debt, genuine smart-infrastructure moat. Up 15% recently, so you're paying more for the same quality. |
| 6 | **GRAB** | $3.13 | **67** | Southeast Asian super-app, buying back its own stock at the lows, insiders reportedly buying the dip today. Cheap on every metric relative to growth. BofA just cut its target, which tags real near-term uncertainty. |
| 7 | **NBIS** | $237.33 | **66** | Best AI-infrastructure business on the list, but P/S near 48x is genuinely rich, and today's tape shows a live AI-safety-driven selloff hitting the whole sector. As pure equity with no defined-risk structure, this is the most valuation-sensitive name here. |
| 8 | **IDN** | $2.39 | **64** | Pristine balance sheet — 91% gross margin, zero debt, cash-generative — held back entirely by one customer's unresolved vendor review. As a share, you're buying the balance sheet cheap and betting on a binary resolving well in November. |
| 9 | **ADTN** | $7.13 | **60** | Fiber-buildout turnaround, 0.93x EV/Sales genuinely cheap, but debt/equity of 1.87 in a 4.9% rate world is a real risk you fully absorb as a shareholder with no options cushion. |
| 10 | **BROS** | $37.89 | **58** | RSI at 20.85 — extremely oversold, near 52-week low. Real business, real growth, but 90x price-to-free-cash-flow and decelerating same-store sales make this a mean-reversion bet more than a quality-compounder bet at these levels. |
| 11 | **KRMN** | $34.92 | **54** | 56% revenue growth and a $1.3B backlog are real. Negative free cash flow and the JCap short-thesis are unresolved. November 5 earnings decides which story wins. |
| 12 | **ABSI** | $9.74 | **53** | Eli Lilly's $40M strategic investment is real validation. As straight equity you carry full exposure to a binary clinical readout due before year-end with no downside cushion. |
| 13 | **QXO** | $12.43 | **51** | Brad Jacobs is 5-for-5 across prior roll-ups. 6-7x leveraged against a housing-sensitive business is a real risk you own outright as a shareholder — no defined-loss structure. |
| 14 | **IVVD** | $0.93 | **48** | Approved commercial drug, cash roughly equal to market cap, Phase 3 data due any day. As common stock, full binary exposure both ways — genuinely could be a 5x or a total loss depending on data landing this week. |
| 15 | **YSS** | $9.57 | **46** | Up ~20% off the lows, which is a real recovery signal. But the 96%-customer-concentration allegation and the securities class action are both still unresolved. |
| 16 | **BKSY** | $23.25 | **40** | EBITDA-positive inflection was real, but the re-rating from $15 to $23 has already happened. Buying here means paying up for a story the market has mostly caught onto. |
| 17 | **VELO** | $11.29 | **32** | Down 29% with no confirmed catalyst in what I've verified. Structural ATM dilution was always the risk; something clearly hit the stock hard. Needs investigation before any conclusion — flagging honestly rather than guessing. |
| 18 | **SWMR** | $20.73 | **28** | $310K of revenue against a market cap in the hundreds of millions. Fell 5.64% same-day specifically on dilution and execution concerns tied to the Ratel deal — the exact risk materializing in real time. |
| 19 | **ARBE** | ~$0.60 | **20** | Just priced a dilutive offering with warrants for 24.17 million additional shares — roughly 19% of the share count — at a discount to market. Pre-revenue, cash-burning, and the dilution risk is no longer theoretical. As common stock with no leverage or defined-loss protection, this is the weakest risk/reward on the list right now. |
re: Biotech Long Play: ABVX
Posted by bayoubengals88 on 9/27/26 at 2:20 pm to bayoubengals88
Claude is bullish AF on the TLDR:
Abivax delivered every Phase 3 milestone on schedule — positive UC maintenance data twice, seven-year clean safety profile, NDA filing imminent. The stock ran to $148 on the June data, then faded to $91 when no acquisition announcement came immediately. That's impatient money leaving, not the thesis breaking.
The reason no deal has happened yet: every potential acquirer — AbbVie, Pfizer, BMS, Sanofi — is waiting for the Crohn's disease Phase 2b data due Q4 2026. Positive CD data adds billions to the acquisition price. The NDA filing triggers a PDUFA date, creating urgency for buyers.
$91 is a better entry than $148 was. The deal gets done in 2027.
Abivax delivered every Phase 3 milestone on schedule — positive UC maintenance data twice, seven-year clean safety profile, NDA filing imminent. The stock ran to $148 on the June data, then faded to $91 when no acquisition announcement came immediately. That's impatient money leaving, not the thesis breaking.
The reason no deal has happened yet: every potential acquirer — AbbVie, Pfizer, BMS, Sanofi — is waiting for the Crohn's disease Phase 2b data due Q4 2026. Positive CD data adds billions to the acquisition price. The NDA filing triggers a PDUFA date, creating urgency for buyers.
$91 is a better entry than $148 was. The deal gets done in 2027.
re: Biotech Long Play: ABVX
Posted by bayoubengals88 on 9/27/26 at 2:11 pm to TheOcean
A little chat…
The chart tells the story clearly and you're reading it right.
**What happened in six months:**
The stock ran from ~$100 to **$148** on the Phase 3 Part 1 announcement June 1. That was the peak — the market pricing in the best possible outcome on the most important data readout. Then it faded all the way back to **$91**, even as Part 2 came in positive June 29 and the seven-year safety data landed clean in July.
The June 29 and July prints should have pushed it higher. They didn't. That's the tell.
**What's actually happening:**
The market bid up ABVX to $148 pricing in an imminent acquisition announcement. When no deal was announced in June, July, or August, the "where's the acquirer?" frustration set in and the stock bled back down. This is a classic **"buy the rumor, sell the news" dynamic** — except the news was genuinely excellent, which makes the selloff more of a timing disappointment than a fundamental one.
At $91 and a €7.06B market cap, you're back to roughly **pre-Phase 3 maintenance data levels** despite having:
- Phase 3 Part 1 positive ?
- Phase 3 Part 2 positive ?
- Seven-year safety data clean ?
- NDA filing Q4 2026 imminent ?
- Crohn's data coming Q4 2026 ?
**Is it a shakeout? Almost certainly yes.**
The 11.13% six-month decline on a company that delivered every clinical milestone on schedule, with no negative data, no safety signals, no financing emergency, and a NDA filing weeks away — that's sentiment, not fundamentals. The weak hands who bought at $148 expecting an immediate takeout announcement have been selling to whoever is patient enough to wait for the actual deal.
**The acquisition thesis is actually stronger at $91 than it was at $148** — the same asset, the same data, at a 39% lower price for the acquirer. AbbVie, Pfizer, BMS, and Sanofi are all looking at a clean Phase 3 UC asset with Crohn's data incoming, a NDA filed, and a market cap that's given back a third of its peak. That's a more attractive entry for a strategic buyer than it was at $148.
**The two catalysts that end the shakeout:**
NDA acceptance by the FDA — expected Q4 2026 once the filing is received. An accepted NDA sets a PDUFA date (the FDA decision deadline, typically 12 months from acceptance). The moment a PDUFA date exists, acquirers know exactly when they need to close a deal by. That creates urgency.
Crohn's disease Phase 2b data — also Q4 2026. Positive CD data adds the second indication to the acquisition package and raises the price floor for a deal. This is why no one has announced yet — every sophisticated buyer is waiting to see the Crohn's data before bidding, because it changes the value of what they're buying by $2-3 billion.
**My read:** you're watching patient money accumulating between $90-100 while the weak hands exit, ahead of a Q4 2026 that delivers both the NDA filing and the Crohn's data within weeks of each other. When both of those land simultaneously, the acquisition dynamic resumes — with a cleaner story, a PDUFA date, and Crohn's optionality added to the package.
The shakeout is real. The thesis is intact. The acquirer is waiting for Q4 before bidding. So should you.
CAN I GET $80?!?
The chart tells the story clearly and you're reading it right.
**What happened in six months:**
The stock ran from ~$100 to **$148** on the Phase 3 Part 1 announcement June 1. That was the peak — the market pricing in the best possible outcome on the most important data readout. Then it faded all the way back to **$91**, even as Part 2 came in positive June 29 and the seven-year safety data landed clean in July.
The June 29 and July prints should have pushed it higher. They didn't. That's the tell.
**What's actually happening:**
The market bid up ABVX to $148 pricing in an imminent acquisition announcement. When no deal was announced in June, July, or August, the "where's the acquirer?" frustration set in and the stock bled back down. This is a classic **"buy the rumor, sell the news" dynamic** — except the news was genuinely excellent, which makes the selloff more of a timing disappointment than a fundamental one.
At $91 and a €7.06B market cap, you're back to roughly **pre-Phase 3 maintenance data levels** despite having:
- Phase 3 Part 1 positive ?
- Phase 3 Part 2 positive ?
- Seven-year safety data clean ?
- NDA filing Q4 2026 imminent ?
- Crohn's data coming Q4 2026 ?
**Is it a shakeout? Almost certainly yes.**
The 11.13% six-month decline on a company that delivered every clinical milestone on schedule, with no negative data, no safety signals, no financing emergency, and a NDA filing weeks away — that's sentiment, not fundamentals. The weak hands who bought at $148 expecting an immediate takeout announcement have been selling to whoever is patient enough to wait for the actual deal.
**The acquisition thesis is actually stronger at $91 than it was at $148** — the same asset, the same data, at a 39% lower price for the acquirer. AbbVie, Pfizer, BMS, and Sanofi are all looking at a clean Phase 3 UC asset with Crohn's data incoming, a NDA filed, and a market cap that's given back a third of its peak. That's a more attractive entry for a strategic buyer than it was at $148.
**The two catalysts that end the shakeout:**
NDA acceptance by the FDA — expected Q4 2026 once the filing is received. An accepted NDA sets a PDUFA date (the FDA decision deadline, typically 12 months from acceptance). The moment a PDUFA date exists, acquirers know exactly when they need to close a deal by. That creates urgency.
Crohn's disease Phase 2b data — also Q4 2026. Positive CD data adds the second indication to the acquisition package and raises the price floor for a deal. This is why no one has announced yet — every sophisticated buyer is waiting to see the Crohn's data before bidding, because it changes the value of what they're buying by $2-3 billion.
**My read:** you're watching patient money accumulating between $90-100 while the weak hands exit, ahead of a Q4 2026 that delivers both the NDA filing and the Crohn's data within weeks of each other. When both of those land simultaneously, the acquisition dynamic resumes — with a cleaner story, a PDUFA date, and Crohn's optionality added to the package.
The shakeout is real. The thesis is intact. The acquirer is waiting for Q4 before bidding. So should you.
CAN I GET $80?!?
re: Biotech Long Play: ABVX
Posted by bayoubengals88 on 9/27/26 at 9:38 am to TheOcean
The valuation isn’t low…
What are people expecting 15bn?
And who needs the drug?
What are people expecting 15bn?
And who needs the drug?
re: Biotech Long Play: ABVX
Posted by bayoubengals88 on 9/27/26 at 9:11 am to TheOcean
Knowing that all investment risks are our own, what about ABVX would allow us to size large and hold or add through drawdowns?
What do you know about management?
What do you know about management?
re: Biotech Long Play: ABVX
Posted by bayoubengals88 on 9/27/26 at 8:59 am to TheOcean
:bow:
Would love too see possible gains of IVVD go into this.
Or, I may chicken out on IVVD on Monday (if I can). You know what I’m talking about.
Would love too see possible gains of IVVD go into this.
Or, I may chicken out on IVVD on Monday (if I can). You know what I’m talking about.
re: I did not realize the amount of money Netflix makes..
Posted by bayoubengals88 on 9/26/26 at 2:51 pm to Cosmo
quote:They can start by producing better content.
Netflix cant grow much more, can only raise prices
We only pay for Apple and Disney+
Simply dropped NFLX because we prefer Apple TV.
And we have Amazon of course…
re: One of the most inept final series I've ever seen courtesy of the soft Vols.
Posted by bayoubengals88 on 9/26/26 at 2:48 pm to DmitriKaramazov
That was fricking terrible.
Deserved to lose.
Deserved to lose.
re: Netflix (NFLX) where does it go from here?
Posted by bayoubengals88 on 9/26/26 at 2:42 pm to jerryc436
That’s about what I spent on them too.
Purely bought because $70 seems like strong support.
May bail if support breaks.
Purely bought because $70 seems like strong support.
May bail if support breaks.
re: Got a bad feeling about tonight guys
Posted by bayoubengals88 on 9/26/26 at 2:38 pm to genuineLSUtiger
What’s it like being a real bitch?
re: I did not realize the amount of money Netflix makes..
Posted by bayoubengals88 on 9/26/26 at 12:36 pm to i am dan
I don’t understand how any grown adult doesn’t follow the stock market :lol:
re: Why is Warren Buffett so revered?
Posted by bayoubengals88 on 9/26/26 at 10:27 am to beaverfever
quote:
He comes from the school of “find companies that are massively cheap by any measure and buy them.” It wasn’t easy but it was possible. It’s not a thing anymore.
I literally just tried this approach with GRAB. I thought NBIS was cheap at 7bn cap and OUST below 2.
That’s still how everyone picks stocks right??
re: Netflix (NFLX) where does it go from here?
Posted by bayoubengals88 on 9/26/26 at 10:21 am to jerryc436
On second thought I may just sit on them.
Got Jan 2028s for 9.75
$85 strike
Got Jan 2028s for 9.75
$85 strike
re: What will Brian Kelly’s legacy be in LSU lore?
Posted by bayoubengals88 on 9/25/26 at 7:13 pm to genuineLSUtiger
Dancing weird and pounding tables.
re: PGEN stock -- potential solid long
Posted by bayoubengals88 on 9/25/26 at 7:05 pm to TheOcean
Invaluable. :cheers:
A word in IBRX? ABSI?
A word in IBRX? ABSI?
re: OUST - Ouster LiDAR for Physical AI
Posted by bayoubengals88 on 9/25/26 at 4:01 pm to jerryc436
:drool:

re: Why is Warren Buffett so revered?
Posted by bayoubengals88 on 9/25/26 at 3:42 pm to bayoubengals88
Ken Griffin belongs in the conversation — and he's genuinely underrated in public discourse. Here's the full picture:
The numbers: From 1990 through 2024, Citadel has produced compound annual returns of 19.5%. Citadel's flagship Wellington fund has delivered annualized returns after fees of ~19.1% since inception, according to an investor in the fund. That puts him right alongside Buffett on long-run annualized return — but Buffett didn't charge 2-and-20.
Scale: Citadel has grown to about $67 billion in assets under management as of early August 2025. That's institutional at the highest level — not a personal account, not a small fund.
Peak year: In 2022, Citadel chalked up a $16 billion profit for investors, making it the best ever annual return for a hedge fund — surpassing John Paulson's previous record of $15.6 billion in 2007. In that same year, the average hedge fund lost 4.25%, while Citadel's flagship Wellington fund returned 38.1%.
The ugly asterisk: Citadel came close to collapse during the 2008–09 financial crisis, reporting a 55% loss that wouldn't be fully recovered until 2012, and was forced to suspend withdrawals — a restriction that infuriated investors. That's the single biggest knock on Griffin's record. Druckenmiller had zero down years. Griffin nearly blew up.
The numbers: From 1990 through 2024, Citadel has produced compound annual returns of 19.5%. Citadel's flagship Wellington fund has delivered annualized returns after fees of ~19.1% since inception, according to an investor in the fund. That puts him right alongside Buffett on long-run annualized return — but Buffett didn't charge 2-and-20.
Scale: Citadel has grown to about $67 billion in assets under management as of early August 2025. That's institutional at the highest level — not a personal account, not a small fund.
Peak year: In 2022, Citadel chalked up a $16 billion profit for investors, making it the best ever annual return for a hedge fund — surpassing John Paulson's previous record of $15.6 billion in 2007. In that same year, the average hedge fund lost 4.25%, while Citadel's flagship Wellington fund returned 38.1%.
The ugly asterisk: Citadel came close to collapse during the 2008–09 financial crisis, reporting a 55% loss that wouldn't be fully recovered until 2012, and was forced to suspend withdrawals — a restriction that infuriated investors. That's the single biggest knock on Griffin's record. Druckenmiller had zero down years. Griffin nearly blew up.
re: Why is Warren Buffett so revered?
Posted by bayoubengals88 on 9/25/26 at 3:39 pm to ItzMe1972
Warren Buffett is the undisputed long-duration champion. From 1965 through end of 2024, Berkshire's shares rose 5,502,284% — a 19.9% annualized compound return vs the S&P's 10.4% over the same six decades. The caveat: over the last 10–20 years it's been a different story — Berkshire has trailed the market since January 2009. His edge is duration — no one else has beaten the market across 60 years.
Peter Lynch posted the highest rate of return of any institutional manager over his run. The Magellan Fund generated a 29% annualized compound return after fees during Lynch's 13-year tenure, delivering cumulative returns of 27 times — while the S&P 500 gained only 4.7 times over the same period. Despite those 29% annualized returns over 13 years, the average Magellan investor actually lost money — because investors consistently bought after strong performance and sold after drawdowns. A lesson unto itself.
Stanley Druckenmiller is arguably the most impressive on a risk-adjusted basis. As the Quantum Fund's lead portfolio manager, he helped George Soros pull off one of the single greatest trades — breaking the Bank of England in 1992 with a bet against the British pound that netted a $1B payday. By the time he closed Duquesne in 2010, he had generated 30% average annual returns with no down years across nearly three decades. Zero losing years over 30 years may be the single hardest feat in this group — Buffett and Lynch both had down stretches relative to the market.
For fun:
Chris Camillo is the outlier — spectacular raw numbers, but with major asterisks. His nearly 15-year track record from 2006 to 2020 boasts an average 77% annual compounded return, confirmed by Jack Schwager, starting with a balance of $84,000 and growing to $42 million in cumulative profits by May 2021. The critical limits: this is a personal account, not institutional capital. Strategy scalability is essentially zero — his approach involves data-mining social media platforms to identify and capitalize on early trends before they become mainstream. You can't run that at $10B. Druckenmiller himself noted that managing more than $10B strained his ability to maintain returns.
Peter Lynch posted the highest rate of return of any institutional manager over his run. The Magellan Fund generated a 29% annualized compound return after fees during Lynch's 13-year tenure, delivering cumulative returns of 27 times — while the S&P 500 gained only 4.7 times over the same period. Despite those 29% annualized returns over 13 years, the average Magellan investor actually lost money — because investors consistently bought after strong performance and sold after drawdowns. A lesson unto itself.
Stanley Druckenmiller is arguably the most impressive on a risk-adjusted basis. As the Quantum Fund's lead portfolio manager, he helped George Soros pull off one of the single greatest trades — breaking the Bank of England in 1992 with a bet against the British pound that netted a $1B payday. By the time he closed Duquesne in 2010, he had generated 30% average annual returns with no down years across nearly three decades. Zero losing years over 30 years may be the single hardest feat in this group — Buffett and Lynch both had down stretches relative to the market.
For fun:
Chris Camillo is the outlier — spectacular raw numbers, but with major asterisks. His nearly 15-year track record from 2006 to 2020 boasts an average 77% annual compounded return, confirmed by Jack Schwager, starting with a balance of $84,000 and growing to $42 million in cumulative profits by May 2021. The critical limits: this is a personal account, not institutional capital. Strategy scalability is essentially zero — his approach involves data-mining social media platforms to identify and capitalize on early trends before they become mainstream. You can't run that at $10B. Druckenmiller himself noted that managing more than $10B strained his ability to maintain returns.
re: OUST - Ouster LiDAR for Physical AI
Posted by bayoubengals88 on 9/25/26 at 2:10 pm to jerryc436
Only you can make that call.
I think we'll keep climbing if options flow is any indication.
It's really strong and the chart says there's plenty of room to run in the months ahead.
That said, I can see it cooling off next week to around $40.
It may be good to recoup some cash and then go further out and at a lower price. That way you're still catching upside.
I think we'll keep climbing if options flow is any indication.
It's really strong and the chart says there's plenty of room to run in the months ahead.
That said, I can see it cooling off next week to around $40.
It may be good to recoup some cash and then go further out and at a lower price. That way you're still catching upside.
re: PGEN stock -- potential solid long
Posted by bayoubengals88 on 9/25/26 at 1:29 pm to Fat Bastard
I'm very sorry to hijack, but I wanted to put IVVD on y'alls radar.
Phase 3 readout is expected today or next week.
277mm market cap
160mm cash
0 debt
TTM Revenue 55mm
3-4 quarters of runway
If the company gets acquired for $5 billion or more, the CEO personally receives 0.5% to 1.5% of the total deal price.
On a $5 billion sale that's $25 to $75 million bonus.
He was handed that agreement days before the Phase 3 data drops.
What's the drug about? (VYD2311)
Big Pharma has spent years and hundreds of millions of dollars on a simple question:
Can we give people a shot that prevents COVID — without it being a vaccine?
Not mRNA. Not spike proteins. Just pre-made antibodies, injected into your arm twice a year, that fight COVID before it can make you sick. The same kind of antibodies your body would make naturally if it beat the virus — just delivered directly, skipping the whole immune system process entirely.
They recruited 2,400 volunteers. Half got the shot. Half got a placebo. Nobody knew which was which. Then they watched who got COVID.
The results come out in the next five days.
If the shot worked — meaning significantly fewer people in the antibody group got COVID compared to the placebo group — the company goes to the FDA and says: approve this. If approved, there's finally a non-vaccine option for the millions of people who've stopped getting COVID shots but are still worried about getting seriously ill. Older people. Immunocompromised people. People who don't want mRNA but do want protection.
If it didn't work, the company is in serious trouble. Their only approved product is on a regulatory clock, (that's the 55mm revenue) their cash runs out in about a year, and there's no backup plan big enough to matter.
Our favorite...
The point in plain English:
The FDA required Pfizer, Moderna, and Novavax to run massive, expensive post-approval studies as a condition of their COVID vaccine approvals. Tens of thousands of patients, years of follow-up, onerous safety monitoring requirements.
The FDA told Invivyd the bar to file and potentially approve VYD2311 is lower than what they demanded from the vaccine makers.
That's a meaningful regulatory signal. It means either the FDA views antibody-based prevention as lower-risk than mRNA vaccines and therefore requiring less post-market scrutiny — or the political environment under RFK Jr.'s influence on health policy has made the agency more accommodating to non-vaccine COVID prevention approaches — or both.
The RFK Jr. angle is the politically charged part. The new administration is openly skeptical of mRNA vaccines. An agency operating under that political environment may be more favorably disposed toward approving an alternative that gives vaccine-hesitant Americans a different option. That's not conspiracy — it's regulatory politics, which has always influenced FDA decision-making regardless of who's in charge.
The "kinda makes you go hmmmm" is Feuerstein — who is one of the more credible biotech journalists in the business — noting that the regulatory path for VYD2311 appears easier than the path was for the products it's competing against. Whether that's fair or scientifically justified is a separate debate. What it means for the investment is that the approval probability may be higher than a standard Phase 3 success rate would imply.
Phase 3 readout is expected today or next week.
277mm market cap
160mm cash
0 debt
TTM Revenue 55mm
3-4 quarters of runway
If the company gets acquired for $5 billion or more, the CEO personally receives 0.5% to 1.5% of the total deal price.
On a $5 billion sale that's $25 to $75 million bonus.
He was handed that agreement days before the Phase 3 data drops.
What's the drug about? (VYD2311)
Big Pharma has spent years and hundreds of millions of dollars on a simple question:
Can we give people a shot that prevents COVID — without it being a vaccine?
Not mRNA. Not spike proteins. Just pre-made antibodies, injected into your arm twice a year, that fight COVID before it can make you sick. The same kind of antibodies your body would make naturally if it beat the virus — just delivered directly, skipping the whole immune system process entirely.
They recruited 2,400 volunteers. Half got the shot. Half got a placebo. Nobody knew which was which. Then they watched who got COVID.
The results come out in the next five days.
If the shot worked — meaning significantly fewer people in the antibody group got COVID compared to the placebo group — the company goes to the FDA and says: approve this. If approved, there's finally a non-vaccine option for the millions of people who've stopped getting COVID shots but are still worried about getting seriously ill. Older people. Immunocompromised people. People who don't want mRNA but do want protection.
If it didn't work, the company is in serious trouble. Their only approved product is on a regulatory clock, (that's the 55mm revenue) their cash runs out in about a year, and there's no backup plan big enough to matter.
Our favorite...
Loading Twitter/X Embed...
If tweet fails to load, click here. The point in plain English:
The FDA required Pfizer, Moderna, and Novavax to run massive, expensive post-approval studies as a condition of their COVID vaccine approvals. Tens of thousands of patients, years of follow-up, onerous safety monitoring requirements.
The FDA told Invivyd the bar to file and potentially approve VYD2311 is lower than what they demanded from the vaccine makers.
That's a meaningful regulatory signal. It means either the FDA views antibody-based prevention as lower-risk than mRNA vaccines and therefore requiring less post-market scrutiny — or the political environment under RFK Jr.'s influence on health policy has made the agency more accommodating to non-vaccine COVID prevention approaches — or both.
The RFK Jr. angle is the politically charged part. The new administration is openly skeptical of mRNA vaccines. An agency operating under that political environment may be more favorably disposed toward approving an alternative that gives vaccine-hesitant Americans a different option. That's not conspiracy — it's regulatory politics, which has always influenced FDA decision-making regardless of who's in charge.
The "kinda makes you go hmmmm" is Feuerstein — who is one of the more credible biotech journalists in the business — noting that the regulatory path for VYD2311 appears easier than the path was for the products it's competing against. Whether that's fair or scientifically justified is a separate debate. What it means for the investment is that the approval probability may be higher than a standard Phase 3 success rate would imply.
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