CivilTiger83

Bumping my previous question (a couple other posters asked it as well)... do you take any anabolic steroids or health supplements like creatine?

Edit: Nevermind. I see that you answered the question above. Rest up and take it easy! :cheers:

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It hit me this morning that if I get worse and get moved to ICU and don't make it, I won't even be able to say goodbye to my family. Not sure if they can even hold a funeral either.

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Ever read Victor Frankl’s Mans Search for Meaning? I would highly recommend it. Don’t discount the importance of mental discipline and hope during this time. Prayer and rest will do you good. Hang in there.

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Even with all the testing South Korea did, their death rate is running over 1%.

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They stopped the spread in a matter of weeks and didn't shut down the country. They tested at a higher rate than anyone during their crisis and did detailed case tracking (like Singapore).

They had the benefit of getting trained with the outbreaks of the past 20 years from nearby China - that is the one thing we didn't really have that they did.

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Concomitant bacterial pneumonia is incredibly rare in these patients. The potential benefit of azithromycin lies in its inherent anti inflammatory properties. I doubt changing to doxy would benefit patients.

These patients don’t die from their viral pneumonia, they die from the massive inflammatory response and acute respiratory distress syndrome when their lungs fill with fluid. Stopping the massive cytokine storm/inflammatory cascade that causes this is key I think, and I would guess trials looking at tocilizumab (IL-6 inhibitor) or anakinra (IL-1 inhibitor) will be more promising. Just my 2 cents as an ER doc who follows this stuff super closely, for obvious reasons.

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We do have another doc on here who said they prescribed Hydroxychloroquine only, and saw improvement only to see the patient go critical two days later due to a secondary bacterial pneumonia. It's one data point, but interesting nonetheless.

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I eagerly look forward to his published, double blind, randomized controlled trial showing this data.

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The French study looked at viral clearance from the nares, an essentially worthless metric. We need mortality data/patient oriented outcomes, as well as proof of safety, to make better clinical decisions.

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You are parroting the worthless crap from the Twitter keyboard scientists.

Do you really think a double blind study is required to show efficacy? If you are introducing a new long term drug trial it might be... not for an already established drug with a 50 year track record. The amount of positive data relative to a control group can be so overwhelming that there is no need to go through a double blind study.

This doctor is one of the best infectious disease doctors in the world... are you a doctor? Do you publish papers on treating infectious disease? I could care less whether or not his study was airtight... it was a way to measure objectively. Do you know how common it is for an active virus like this to disappear from the nasal cavity and not everywhere else?

Tell me, is NY which is currently doing a much larger trial right now with this treatment regimen doing a double blind study?

My non-medical guess based on all of the anecdotes coming out is that around 90-95% of patients who start treatment before they are in the critical stage will see a real improvement.

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it's easy to say this in hindsight but look at the MENSA posters we have here right now with evidence right in front of them.

imagine if they cancelled mardi gras in the middle of february, there may have been actual riots

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They were a better team than Clemson and blew the game. Clemson was average on defense without 3 1st rders on defense.

OSU would have been a better match up against LSU as they had a better defense and run game than Clemson.

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OSU had a great team, but Clemson had great players as well that made the critical plays. OSU’s head coach is a sore loser. Never seen someone whine so much after a playoff loss.

Agreed DollaChoppa. I wouldn’t be surprised if the spread is 10 to 100 times current estimates with our limited testing.

I hope it’s true, but there are some data points that would suggest that isn’t the case. Nursing homes is the biggest one... if this has infected half the population you would have seen many more cases like the Washington nursing home in January/February. That would have raised alarms pretty quickly.

NY is probably the best statewide dataset at this point (lots of testing with a high number of cases with full reporting). They are showing around a 10% hospitalization rate with a case fatality rate at 0.7%.

There are two competing issues on the case fatality rate. On the one hand, fatalities will lag cases by at least a week. When you consider that cases are doubling every 5-7 days, that means that the true CFR might be double the current raw case fatality rate.

On the other hand with our limited testing there are likely many more cases than we thought. NY is testing more than anyone in the US, so they probably have a decent handle on the denominator... at least within the ballpark.

It appears that NY also has most of its cases in the lower risk category (under 70) so that helps the fatality numbers.

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I don't disagree with testing. I feel it is the only thing that will satisfy people. But the exponential jump in the positive number WILL cause greater panic and more knee jerk reactions.

Testing must be moved to testing sites though. Places where staff are ONLY dressed in PPE and equipped for mass testing. These sites will conserve PPE.

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Disagree that it will cause panic. Let's say tomorrow we know that there are actually 5 million cases of COVID-19 across the US. That would mean it is much closer to working itself through the population with greater herd immunity and it is much less fatal than we thought. ...Not saying that is the actual number, but just saying it is more likely to calm than panic most people.