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apoB or LDL-p is what matters these are measures of the number of particles (lipoproteins). LDL-C is the measure (or calculation) of the total cholesterol.

On average these things generally align; however, the issue is for 3 people with the exact same LDL-C (High):

Person 1 very large lipoproteins (apoB count would be lower)
Person 2 average lipoprotein size (apoB count average)
Person 3 very small lipoproteins (apoB count much higher)

For those three people the "guidelines" all say statin to lower LDL-C. Person 3 is at significantly greater risk and standard of care may not lower their cholesterol levels enough if treating to an LDL-C level. Person 3 has MORE/SMALLER apoB particles, which are more atherogenic and more likely to cause plaques in the arterial walls. Person 2 is average & guidelines are probably fine. Person 1 may not even be at risk.

LDL-C isn't wrong - apoB is just a better measurement, because it incorporates particle size. Also price of apoB tests are negligible (US is way behind Europe on this -- LDL-p tests is very expensive, relative to others).

quote:

Why does the number of apoB particles matter? Meaning what is the mechanism by which they cause heart disease?


ApoB is measuring the size of the particles per above. Smaller particles more easily cause plaques in your arterial walls. Plaques then can rupture and you can die. This is not an opinion, it is a known progression of disease that is the leading cause of death in the USA.
quote:

Graves, 51, maintains an ownership interest of almost 90% in the closely held business, bond offering documents reviewed by Bloomberg show. That stake, along with dividends he’s received, are worth $7.6 billion, according to the Bloomberg Billionaires Index, making him the richest person in Louisiana and the 307th-wealthiest in the world.


quote:

Raising Cane’s is a growing player in the popular chicken category, a competitive market featuring brands like McDonald’s Corp., Restaurant Brands International Inc.-owned Popeyes and Yum! Brands Inc.’s KFC. The Baton Rouge-based company is thriving financially, reporting $3.3 billion in sales for the 12 months ended in June and adjusted earnings of $647 million.


Good for Him

re: New LDL cholesterol treatment

Posted by Duck on 11/16/23 at 11:03 am
What does Repatha run a month? Be great when PSK9 inhibitors get cheaper...

re: New LDL cholesterol treatment

Posted by Duck on 11/16/23 at 11:02 am
quote:

cholesterol is vital. we need it to live. why lower it? we need better standards in the american diet is what we need.


Correct that cholesterol is vital and we need it to live.

We are discussing lowering cholesterol in the bloodstream, which is a small portion of the total cholesterol in the body. That cholesterol in the bloodstream, just happens to significantly increase risk of heart disease (one of the largest killers of humans). So the reason for lowering it (in the bloodstream) is to allow people to live longer, that's why.

re: New LDL cholesterol treatment

Posted by Duck on 11/16/23 at 10:38 am
See above for risk related to LDL. Risk of events are most highly related to LDL levels (not going to get into particle size).

Trigs do matter, but they matter a lot less than LDL. Trigs are also highly variable based on your diet. Not eating crap will significantly reduce trigs. LDL, while it may improve from diet, not nearly as much as Trigs.

re: New LDL cholesterol treatment

Posted by Duck on 11/16/23 at 10:22 am
quote:

Anyone who has been keeping up with the newest research knows this is more important than LDL numbers.


This is false and misleading.

In every age cohort - increasing LDL = increased risk


quote:

Damn, it was 15 minutes late for picking up his smoothie!


It was melted!
Sounds like Duce Chestnut is barely on the team anymore -- not listed as the four corners that we have, not listed on an injury report, and did not travel b/c of a coaches decision.

So Speights is 3rd string even if healthy?
Maybe his first sack since his first game as a Tiger against MSU.

re: Protein - Whey vs. Casein

Posted by Duck on 6/20/23 at 4:56 pm
Study from 2013

Found the above saying it doesn't really matter, but the study was with women's basketball players and super small sample.

re: Protein - Whey vs. Casein

Posted by Duck on 6/20/23 at 4:43 pm
I don't know if "wasting" would be the concern. The concern would be you miss the prime window after workouts to bludgeon your muscles w/ protein, since a chunk of the protein is not immediately available to the muscles.

I honestly don't know, hence the question to the board.

I typically drink coffee w/ two scoops right after a workout and then a shake w/ another two scoops on the way to work ~1.5 hrs after working out.

Just curious if any of this matters or if I am just overthinking all of it. Figured someone on here is much more knowledgeable re: bioavailability.

Protein - Whey vs. Casein

Posted by Duck on 6/20/23 at 3:26 pm
Been using Vital Performance Protein powder (which in general I like) -- just realized it is 20% Whey & 80% Casein.

Are there any actual downsides to this vs. a higher percentage of Whey protein?

What say the experts on this board?

TIA
Not claiming he should be excused -- I don't think anyone is. The narrative around him has always been what could have been...

I can't think of any player that had a similar first 3 games of a college career only to disappear.
Problem with your comparison, not that it is necessarily wrong, is Guice/Fournette played full collegiate careers and had a couple games comparable to Collins. They also played on much better teams.

re: Should He Throw It? [1 image]

Posted by Duck on 10/6/22 at 11:01 am
It is REALLY bad. I suggest everyone watch the second play of the Auburn game at the following link (skycam). Play starts at 17:05
LINK

The play is perfectly designed to get KB the ball in the flats with a RB in front to block for him.

Back motions out of backfield; easy read that KB has a LB in coverage (my dumbass can see it pre-snap); JD doesn't even look his way & throws into double coverage intended for Taylor.

This isn't difficult - he should have never looked at anyone else after the motion put KB on a LB. This isn't not going through your progressions -- he shouldn't have had progressions once you realize your AA WR is matched up on a LB.
Good post. My point is that it is a significant factor in how serious you should evaluate statins or how serious you should try to course correct.

We are all going to die sometime and of something, but family history can help show where you are most at risk of dieing. At that point it is your decision to try to take corrective action to reduce that risk as best you can or just accept it. There isn't a right/wrong. The point I was trying to make is given the circumstances, it seems like atherosclerosis is a significant risk for him (not OP, but Doug-H).

If the only risk factor was high cholesterol and not all three of: high cholesterol, overweight, & significant family history at a young age. I could understand the anti-statin sentiment and would entirely agree with it.
I don't disagree with you, but Family History is a huge issue. It is more determinate than anything else in life. Given that he should do everything in his power to 1) lose weight, 2) eat better, & 3) lower his dam cholesterol.

At this point in his life, he should make drastic changes including strong consideration to a statin. If his other life changes materialize, he can try to get off said statin assuming his cholesterol and other bloodwork remains good.

Statins are massively over prescribed and pushed by doctors at the first sign of high cholestorol; however, given his family history he is a PRIME CANDIDATE. He should do everything to lower his risk of atherosclerosis.

People try to oversimplify things as statin = good or statin = bad. That's bullshite, they are a tool in the toolbox. That tool seems like a great tool for someone who is at real risk of major heart issues before 40.

He could also go pay for a calcium artery scan and get scared by the amount of calcium already in his arteries.
I am by no means a huge statin guy, but this guy has two brothers with MASSIVE heart attacks before they turned 40. Dementia when he is 80+(even if it is a real risk) is the least of his worries.
You should seriously consider reading the book, "Good Calories, Bad Calories" by Gary Taubes. It covers diet/LDL issues in great detail and is highly informative. It isn't an easy read, but based on your family history it is something you should spend significant amount of time with/on. In this book, he reviews tons of historical data and really puts the blame on refined carbohydrates and sugar.

Someone mentioned LDL-P that is a great idea re: additional information that should be tested (it is better indicator of risk that LDL-C, which is the common test). In addition, Lp(a) is another significant risk factor. Despite all of the above, your family history says that this is a big issue for you regardless of what the tests say.

At the end of the day, cholesterol is a subject that most general doctors oversimplify and the medical community has greatly fricked up the life changes to improve cholesterol levels (Thanks Keys/Mcgovern). On the other hand given your family history, you should take this seriously and probably get on a statin.

Read a bit about metabolic syndrome, it is a pre-cursor to type 2 diabetes. There is a reason (outside of smoking) obesity greatly increases the risk of cancer and heart attack. The way to reverse/improve metabolic sydrome is to control insulin levels in your body by eliminate/signifcantly reducing carbs and sugars.

Disclaimer: not a doctor