Liverwort could prove to be more medically effective than cannabis, research suggests

Currently, the medicinal use of cannabinoids, extracted from cannabis, is a subject of debate around the world. In Switzerland, more and more people are advocating for increased research into cannabis. Today, tetrahydrocannabinol (THC) is used in the medical field to deal with certain types of pain, muscle cramps, dizziness and loss of appetite.

However, it is an illegal narcotic and, accordingly, can trigger side effects. THC in its pure form was first isolated from cannabis in 1964 by Raphael Mechoulam at the Weizmann Institute of Science in Israel. Until now, it was thought that cannabis was the only plant that produces THC. However, as early as 1994, Japanese phytochemist Yoshinori Asakawa had discovered a substance in the liverwort plant Radula perrottetii which was related to THC and had named this natural substance "perrottetinene." In this natural product, the individual atoms are linked together in a manner similar to that of THC, however they differ in their three-dimensional structure and further exhibit an additional benzyl group.

A few year ago, Jürg Gertsch from the Institute of Biochemistry and Molecular Medicine at the University of Bern discovered that liverworts were being advertised as so-called "legal highs" on the internet. At the time, nothing was known about the pharmacological effects of this substance. Together with chemists from Erick Carreira's team from the Department of Chemistry at the ETH Zürich, Gertsch's research team in Bern biochemically and pharmacologically compared THC and perrottetinene.







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