re: Let's talk realistic scenarios...

That type of philosophy is overly complicated and is seen more in the NFL where QBs and WRs are more knowledgeable about coverages. It is far less common at the college level and virtually non-existent at HS level.

College and HS coaches OCs typically employ pass plays against zone coverage that will have a high likelihood of the primary receiver moving into the blind spot of a zone at the right time. The progression to a secondary receiver is typically an easy read as that receiver will be in the same zone or one adjacent to the primary receivers zone. The 3rd receiver is usually a decoy to run a corner or a safety away from the targeted zone but can become a primary target when/ if a play breaks down. Unless designed to be the primary (as in a screen) the 4th receiver (usually a RB) is a check down option.

Of course, this all changes when a defense is using press/man coverage as you try to exploit match ups and rely on your players to athletically beat their man to a spot or throwing quick passes to " where they ain't."

But the whole QB/WR adjusting routes synchronization is rare at the college level. That takes a few years of a QB and receivers working together to be effective. Usually, when you see a throw that looks to be way off it is due to the QB or WR screwing up the play call. He ran a 12 yard in when it was supposed to be a 10 yard out or he threw a deep out when he was supposed to throw a 12 yard comeback.