What's the most devastating regular season loss for each football program?

I can think of 3 for UK, but there are just so many to choose from.

1993 Florida loss after 7 interceptions.
Bluegrass Miracle. So Kentucky....
We lost to Tulane I think on 2 phantom pass interference penalties.

All time, yes, that loss to Tennessee is probably the biggest one.

October of 1988.

7-6.

Night game.

I wanted to vomit.

I will speak of it no more.

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Alabama - Kick Six

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I mean, it sucked, and it prevented a 3 peat, but Bama has won 3 SEC titles and a national title since that game. Not sure it devastated the football program

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Alabama - Kick Six

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We would have lost to FSU.

Last year vs Clemson. We were 30 seconds away from another national title.

LSU-Tennessee 1959 cost us back to back NC

MSU most embarrassing is Maine.

But 3-2 Auburn is the worst attempt at football I have ever seen.

I would say the 2014 Egg Bowl. However, the playoff committee would have likely jumped Ohio State over us anyway after they blew out Wisconsin 59-0. So the best we would have had is the Orange Bowl, which is where we ended up.

Aside from that, we had losses against Bama in 1999 and Arky in 2000 which derailed any chances at winning the West in those years.

Oh, and I forgot that our loss to Florida in 1980 cost us a share of the SEC championship.

A&M is 1975 Arkansas and there really isn't a close second.

for LSU, while last year's Florida game was pretty devastating, I'm going to go with Ref Gate.