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re: 4 year long study on Wegovy/semaglutide shows heart benefits and safety

Posted on 5/15/24 at 8:42 am to
Posted by POTUS2024
Member since Nov 2022
11510 posts
Posted on 5/15/24 at 8:42 am to
quote:

Not just obese, but most weights, normal and overweight also. What was failed to mention in the OP post was the most important finding in this trial, and was that they found Cardiovascular benefit without weight loss.


I haven't read this study - how do you get no weight loss with a weight loss drug and then have beneficial CV effects? What's going on there?
Posted by Mo Jeaux
Member since Aug 2008
59109 posts
Posted on 5/15/24 at 8:47 am to
quote:

I haven't read this study - how do you get no weight loss with a weight loss drug and then have beneficial CV effects? What's going on there?


quote:

“It remains unclear to what degree the trial findings were dependent on weight loss, concomitant reductions in risk factors, or other salutary mechanisms of GLP-1 receptor agonism,” Dr. Amit Khera, of the University of Texas Southwestern Medical Center Dallas, and the National Institutes of Health’s Dr. Tiffany M. Powell-Wiley wrote in an editorial that was published Saturday in the New England Journal of Medicine along with the full results of the study, called Select.
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